Effect of photodynamic therapy on the skin using the ultrashort laser ablation.

نویسندگان

  • Gustavo Nicolodelli
  • Dora Patricia Ramírez Angarita
  • Natalia Mayumi Inada
  • Luis Fernando Tirapelli
  • Vanderlei Salvador Bagnato
چکیده

Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro-holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue.

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عنوان ژورنال:
  • Journal of biophotonics

دوره 7 8  شماره 

صفحات  -

تاریخ انتشار 2014